Student seminar reconvenes on April 2. Good luck on exams, and enjoy spring break!
Photo credit: dog_baba
Biostatistics – Recent Articles- Estimation and inference for case-control studies with multiple non-gold standard exposure assessments: with an occupational health application
- A novel approach to cancer staging: application to esophageal cancer
- Variable selection and dependency networks for genomewide data
- A semiparametric 2-part mixed-effects heteroscedastic transformation model for correlated right-skewed semicontinuous data
- Rank-based estimation in the {ell}1-regularized partly linear model for censored outcomes with application to integrated analyses of clinical predictors and gene expression data
- Int Jnl of Biostatistics – Recent Articles
- Modeling Cumulative Incidences of Dementia and Dementia-Free Death Using a Novel Three-Parameter Logistic Function
- Mixed-Effects Models for Conditional Quantiles with Longitudinal Data
- Measures to Summarize and Compare the Predictive Capacity of Markers
- Using Generalized Additive Models to Detect and Estimate Threshold Associations
- On the Use of K-Fold Cross-Validation to Choose Cutoff Values and Assess the Performance of Predictive Models in Stepwise Regression
- COBRA – Recent submissions
- Quasi-Least Squares with Mixed Linear Correlation Structures
- Composite Likelihood EM Algorithm with Applications to Multivariate Hidden Markov Model
- A Permutation-Based Multiple Testing Method for Time-Course Microarray Experiments
- Shrinkage Estimation of Expression Fold Change As an Alternative to Testing Hypotheses of Equivalent Expression
- Bringing Game Theory to Hypothesis Testing: Establishing Finite Sample Bounds on Inference
03/12/08: Alzheimer’s Disease
March 11, 2008 — julianwMichael Sachs
Alzheimer’s Disease (AD) is the most prevalent cause of dementia and is a huge emotional and financial burden. It is estimated that 25%-50% of people over the age of 85 have symptoms of AD. AD was first characterized by Alois Alzheimer in 1906, who considered both clinical and pathological evidence in distinguishing it from other types of dementia. The pathological features of AD include neurofibrillary tangles and senile plaques observed in the brain. These lesions are mostly composed of abnormally processed peptides. In this talk I review these features and the hypothesized chemical pathways that lead to abnormal processing. I also discuss modern imaging technology and its role in further characterizing AD in vivo.
